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    E-Prescribing

    E-prescribing software with Surescripts routing and EPCS

    We build eRx into clinical apps and EHRs — Surescripts network connectivity, EPCS for controlled substances, and a live drug database with interaction, allergy, and formulary checks at the point of prescribing.

    HIPAA-ReadySurescriptsEPCSAudit Logged

    Trusted by global innovators

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    Chibasco
    Fundency
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    Lauren
    Lera
    One Minute
    Pento Pix
    TAP
    Xtrium
    Healthevolve
    Benchmark
    Chibasco
    Fundency
    Lantimer
    Lauren
    Lera
    One Minute
    Pento Pix
    TAP
    Xtrium
    Healthevolve
    Benchmark
    Chibasco
    Fundency
    Lantimer
    Lauren
    Lera
    One Minute
    Pento Pix
    TAP
    Xtrium
    Healthevolve
    Benchmark
    Chibasco
    Fundency
    Lantimer
    Lauren
    Lera
    One Minute
    Pento Pix
    TAP
    Xtrium
    Healthevolve

    What e-prescribing actually requires

    E-prescribing is more than sending a fax replacement. A production eRx module routes prescriptions over the Surescripts network using the NCPDP SCRIPT standard, checks the drug against an interaction and allergy database in real time, and confirms the medication against the patient's formulary and benefit before the clinician signs. Getting any of those wrong pushes work — and risk — back onto the pharmacy and the patient.

    Controlled substances raise the bar further. EPCS (Electronic Prescribing for Controlled Substances) requires DEA-compliant identity proofing, two-factor authentication, and a tamper-evident audit trail on every transaction. We build the full loop — drug database, benefit and formulary checks, medication history, and EPCS — so prescribing is safe, compliant, and fast in the exam room.

    What it is

    The full prescribing loop, not just a send button

    E-prescribing routes a prescription electronically from the clinician to the pharmacy over the Surescripts network, with safety and benefit checks built into the moment of ordering. It replaces phone and fax with a structured, auditable, standards-based transaction.

    A complete module handles new orders, renewals, changes, cancellations, controlled substances via EPCS, and medication history reconciliation — all written back to the chart with a compliant audit trail.

    Prescribing architecture

    See how we wire Surescripts connectivity, the drug database, EPCS identity proofing, and EHR write-back across the prescribing workflow.

    Clinician e-prescribing medication within a connected clinical platform

    What we build into e-prescribing

    Each capability ties a prescribing step to the network, standard, or database that makes it safe.

    15-Minute Scoping Call

    Surescripts network routing

    Certified connectivity to the Surescripts network using NCPDP SCRIPT for new prescriptions, renewals, change requests, and cancellations — routed to the patient's chosen pharmacy in real time.

    EPCS for controlled substances

    DEA-compliant Electronic Prescribing for Controlled Substances with identity proofing, two-factor authentication, and a tamper-evident audit trail on every Schedule II–V transaction.

    Drug database & interactions

    Integration with a licensed drug database (First Databank, Medi-Span, or RxNorm-mapped) for real-time drug-drug, drug-allergy, and duplicate-therapy checking at the point of order.

    Formulary & benefit checks

    Real-time prescription benefit and formulary lookups so clinicians see coverage, prior-auth flags, and lower-cost alternatives before the prescription is signed.

    Medication history

    Pull patient medication history from the network to reconcile active meds, surface adherence gaps, and reduce duplicate or conflicting prescriptions.

    EHR write-back & audit

    Every prescription, change, and cancellation is written back to the chart and logged in an immutable audit trail aligned to HIPAA and DEA recordkeeping requirements.

    Where it runs

    Prescribing use cases we build for

    EHR eRx modules

    Embedded prescribing inside an EHR or clinical documentation product.

    Telemedicine prescribing

    eRx integrated into virtual visits with pharmacy routing and EPCS.

    Specialty & behavioral health

    Controlled-substance workflows for psychiatry, pain, and addiction medicine.

    Urgent care & retail clinics

    Fast prescribing with formulary checks for high-throughput settings.

    Digital health platforms

    Consumer-facing care apps that need compliant prescribing built in.

    Medication management

    Reconciliation and adherence tools built on network medication history.

    Prescribing that clears certification

    eRx fails when certification and EPCS are treated as afterthoughts. We plan them from week one and build the safety checks in, not on.

    NCPDP SCRIPT
    Surescripts network standard
    EPCS
    DEA-compliant controlled substances
    Real-time
    Interaction & formulary checking

    Compliance-First Healthcare App Development Services Backed by Global Standards

    15-Minute Scoping Call
    01HIPAA logo

    HIPAA

    Health Insurance Portability and Accountability Act

    Protect PHI with privacy-first architecture, encrypted storage and transmission, strict access controls, and traceable audit logs.

    02GDPR logo

    GDPR

    General Data Protection Regulation

    Implement lawful consent flows, data minimization, retention controls, and secure processing for sensitive health data.

    03FHIR logo

    FHIR

    Fast Healthcare Interoperability Resources

    Enable standardized health data exchange across apps, care teams, and systems through robust FHIR-ready APIs.

    04HL7 logo

    HL7

    Health Level Seven International

    Support enterprise-grade interoperability with HL7-based integrations for records, events, and clinical messaging workflows.

    05HITRUST logo

    HITRUST

    Health Information Trust Alliance

    Align security programs to healthcare-specific control and risk management practices trusted by providers and ecosystem partners.

    06HITECH logo

    HITECH

    Health Information Technology for Economic and Clinical Health Act

    Design with breach notification readiness, digital record safeguards, and operational controls that support regulated care programs.

    07SaMD logo

    SaMD

    FDA Software as a Medical Device

    Plan software quality, traceability, and documentation pathways for products that may require SaMD review and submission.

    08MDR (EU) logo

    MDR (EU)

    Medical Device Regulation (European Union)

    Prepare EU market-ready processes for risk classification, evidence tracking, and lifecycle governance under MDR expectations.

    09SAMHSA logo

    SAMHSA

    Substance Abuse and Mental Health Services Administration

    Apply confidentiality controls and consent-aware sharing models for behavioral and mental health data experiences.

    Standards we build against

    Prescribing standards in our SDLC

    NCPDPEPCSRxNormFHIRHIPAA
    Our Process

    How we ship e-prescribing

    Surescripts certification, drug-database integration, and EPCS provisioning run in parallel so the module reaches production prescribing, not a sandbox demo.

    1.

    Discovery & certification path

    We map your prescribing workflows, target pharmacies, and the Surescripts certification and EPCS requirements before building, so nothing stalls at go-live.

    Compliance-first design
    2.

    Drug database & checks

    We integrate the drug database and build real-time interaction, allergy, and duplicate-therapy checking into the ordering flow.

    Patient-safety core
    3.

    Surescripts & EPCS

    We connect to the Surescripts network via NCPDP SCRIPT and implement DEA-compliant EPCS identity proofing and two-factor signing for controlled substances.

    Network certified
    4.

    Testing & go-live

    Certification testing, formulary and benefit validation, and phased rollout with prescription-status dashboards and failed-transaction alerting.

    Always audit-ready

    Featured case study

    Read Case Study

    Lera Health: compliant women's health platform

    Related proof of compliant delivery: on Lera Health we built the privacy-first data layer and secure clinical workflows end to end — the same discipline around identity, PHI handling, and auditability that certified prescribing demands.

    Lera Health app across desktop and mobile
    Why Partner With Us

    Why teams build eRx with us

    Prescribing is safety-critical and heavily regulated. We bring the standards fluency and compliance discipline it demands.

    15-Minute Scoping Call

    Compliance-first by default

    EPCS, DEA identity proofing, and HIPAA audit controls designed into the workflow from sprint one — not retrofitted before certification.

    Standards & network fluency

    NCPDP SCRIPT, Surescripts, and RxNorm are part of our vocabulary, so your team isn't explaining the network to us.

    Faster path to certified

    We plan Surescripts certification and EPCS provisioning into the schedule as parallel tracks, not last-minute blockers.

    Workflow-obsessed UX

    Prescribing that fits the exam-room rhythm — fast search, sane defaults, and interaction alerts that inform instead of nag.

    Our prescribing experience

    Built for the exam room

    Frequently Asked Questions

    Cost depends on whether you need standard prescribing only or full EPCS for controlled substances, plus drug-database licensing. Basic eRx routing is a smaller module; adding EPCS identity proofing, formulary checks, and medication history makes it a multi-month effort. We scope in phases and factor third-party licensing (drug database, Surescripts) into the estimate up front.

    Adding e-prescribing to your platform?

    Tell us your prescribing workflows and whether you need EPCS. We'll return a phased plan covering Surescripts certification, drug-database integration, and EHR write-back.

    Email

    contact@agnotic.com

    Partnerships

    contact@agnotic.com